SCHEMBL24539461 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	10/20	0.42

▸	JAK1	P23458	10/20	0.42

▸	TYK2	P29597	10/20	0.42

▸	JAK3	P52333	9/20	0.42

▸	EPHB4	P54760	1/20	0.40

▸	TEK	Q02763	1/20	0.40

▸	F2RL3	Q96RI0	1/20	0.37

▸	TRPV3	Q8NET8	2/20	0.36

▸	NPBWR1	P48145	1/20	0.35

▸	NTRK1	P04629	4/20	0.34

▸	CSF1R	P07333	4/20	0.34

▸	NTRK2	Q16620	4/20	0.34

▸	KCNH2	Q12809	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24539590	1.00	JAK2 (0.42)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24539588	0.88	JAK2 (0.44)	JAK2JAK1TYK2JAK3KCNH2
SCHEMBL24328767	0.83	JAK2 (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24539587	0.83	JAK2 (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24327405	0.81	JAK2 (0.42)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24328770	0.78	EPHB4 (0.41)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL29732889	0.78	JAK2 (0.38)	JAK2JAK1TYK2JAK3F2RL3
SCHEMBL24327771	0.77	TEK (0.43)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL24327878	0.73	EPHB4 (0.42)	JAK2JAK1TYK2JAK3EPHB4
SCHEMBL29498944	0.71	JAK2 (0.35)	JAK2JAK1TYK2JAK3EPHB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022127753-A1	FUSED RING AHR INHIBITOR	山东轩竹医药科技有限公司	2022-06-23	—	—	WO	disclosed