Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.64 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23087658 | 1.00 | PRMT5 (0.64) | PRMT5WDR77RXFP1CYP3A4TSHR | |
| SCHEMBL27002364 | 0.89 | PRMT5 (0.61) | PRMT5WDR77RXFP1GAAKMT2A | |
| SCHEMBL29915065 | 0.89 | PRMT5 (0.61) | PRMT5WDR77RXFP1GAAKMT2A | |
| SCHEMBL31496831 | 0.86 | PRMT5 (0.60) | PRMT5WDR77RXFP1CYP3A4TSHR | |
| SCHEMBL23087513 | 0.85 | PRMT5 (0.67) | PRMT5WDR77HSD17B10ARRECQL | |
| SCHEMBL29735135 | 0.85 | PRMT5 (0.67) | PRMT5WDR77HSD17B10ARRECQL | |
| SCHEMBL29735278 | 0.84 | PRMT5 (0.69) | PRMT5WDR77CYP3A4CYP2C19LMNA | |
| SCHEMBL23087447 | 0.84 | PRMT5 (0.69) | PRMT5WDR77CYP3A4CYP2C19LMNA | |
| SCHEMBL31496822 | 0.83 | PRMT5 (0.53) | PRMT5WDR77RXFP1CYP3A4TSHR | |
| SCHEMBL30752949 | 0.83 | PRMT5 (0.53) | PRMT5WDR77RXFP1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | disclosed |
| EP-4028388-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |