Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915065 | 1.00 | PRMT5 (0.61) | PRMT5WDR77KMT2AADRA1DADRA1A | |
| SCHEMBL23087658 | 0.89 | PRMT5 (0.64) | PRMT5WDR77KMT2APARP1RXFP1 | |
| SCHEMBL29735166 | 0.89 | PRMT5 (0.64) | PRMT5WDR77KMT2APARP1RXFP1 | |
| SCHEMBL30752949 | 0.85 | PRMT5 (0.53) | PRMT5WDR77KMT2APARP1CYP1B1 | |
| SCHEMBL31496822 | 0.85 | PRMT5 (0.53) | PRMT5WDR77KMT2APARP1CYP1B1 | |
| SCHEMBL31496831 | 0.84 | PRMT5 (0.60) | PRMT5WDR77PARP1CYP1B1RXFP1 | |
| SCHEMBL31496856 | 0.84 | PRMT5 (0.55) | PRMT5WDR77KMT2AGRM5PARP1 | |
| SCHEMBL29735135 | 0.84 | PRMT5 (0.67) | PRMT5WDR77PARP1CYP1B1 | |
| SCHEMBL23087513 | 0.84 | PRMT5 (0.67) | PRMT5WDR77PARP1CYP1B1 | |
| SCHEMBL23087447 | 0.82 | PRMT5 (0.69) | PRMT5WDR77KMT2AGRM5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | MIRATI THERAPEUTICS INC (US) | 2024-06-27 | — | — | US | disclosed |
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | PRMT1, PRMT5, PRMT6 | PRMT5 2/4885WDR77 393/4885KMT2A 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.