Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.53 |
| ▸ | EIF2AK3 | Q9NZJ5 | 8/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.44 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | NEK4 | P51957 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043888 | 1.00 | RIPK1 (0.53) | RIPK1EIF2AK3AURKBKDRAURKA | |
| SCHEMBL23044652 | 0.93 | EIF2AK3 (0.54) | RIPK1EIF2AK3AURKBKDRAURKA | |
| SCHEMBL29746861 | 0.93 | EIF2AK3 (0.54) | RIPK1EIF2AK3AURKBKDRAURKA | |
| SCHEMBL29746633 | 0.93 | EIF2AK3 (0.46) | RIPK1EIF2AK3NTRK1AXLNTRK2 | |
| SCHEMBL23043982 | 0.93 | EIF2AK3 (0.46) | RIPK1EIF2AK3NTRK1AXLNTRK2 | |
| SCHEMBL23044049 | 0.92 | EIF2AK3 (0.51) | RIPK1EIF2AK3KDRNTRK1AXL | |
| SCHEMBL29746539 | 0.92 | EIF2AK3 (0.51) | RIPK1EIF2AK3KDRNTRK1AXL | |
| SCHEMBL23043859 | 0.91 | EIF2AK3 (0.54) | RIPK1EIF2AK3AURKBKDRAURKA | |
| SCHEMBL23044093 | 0.91 | EIF2AK3 (0.54) | RIPK1EIF2AK3AURKBKDREIF2AK2 | |
| SCHEMBL29746859 | 0.91 | EIF2AK3 (0.54) | RIPK1EIF2AK3AURKBKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. | 2022-11-10 | — | — | US | disclosed |
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | EEF2K, ATF4, MAPKAPK2 | RIPK1 451/4885EIF2AK3 96/4885AURKB 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.