Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | PNMT | P11086 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15079741 | 1.00 | LMNA (0.67) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL8207699 | 1.00 | LMNA (0.67) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL23123473 | 1.00 | LMNA (0.67) | LMNATP53HTTADRB2CYP3A4 | |
| Hydrochloric Acid SCHEMBL14120711 | 0.98 | LMNA (0.64) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL17226299 | 0.83 | HTT (0.45) | LMNATP53HTTCYP3A4HTR2A | |
| SCHEMBL1911434 | 0.82 | LMNA (0.48) | LMNATP53HTTCYP3A4HTR2A | |
| SCHEMBL8295996 | 0.81 | LMNA (0.48) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL3317981 | 0.80 | TP53 (1.00) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL5492924 | 0.80 | TP53 (1.00) | LMNATP53HTTADRB2CYP3A4 | |
| SCHEMBL3899828 | 0.80 | TP53 (1.00) | LMNATP53HTTADRB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031552-A1 | AZOLE-FUSED PYRIDAZIN-3(2H)-ONE DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2022-07-27 | — | — | EP | disclosed |
| CN-114728975-A | Azole-fused pyridazin-3 (2H) -one derivatives | 武田药品工业株式会社 | 2022-07-08 | — | — | CN | disclosed |