SCHEMBL29758157

SCHEMBL29758157

O=C(Nc1cc(Cl)ccc1OCC(F)(F)F)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(C(=O)O)cc1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F11 P03951 12/20 0.45
S1PR1 P21453 1/20 0.43
IDO1 P14902 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.41
PTGER1 P34995 1/20 0.40
KLKB1 P03952 3/20 0.39
KLK1 P06870 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23466522 1.00 F11 (0.45) F11S1PR1IDO1MRGPRX4PTGER1
SCHEMBL23466521 1.00 F11 (0.45) F11S1PR1IDO1MRGPRX4PTGER1
SCHEMBL23486474 0.90 MAPT (0.41) F11S1PR1IDO1KLKB1CYP1A2
SCHEMBL23466496 0.90 F11 (0.46) F11S1PR1IDO1KLK1CYP1A2
SCHEMBL29757988 0.90 F11 (0.46) F11S1PR1IDO1KLK1CYP1A2
SCHEMBL23466497 0.90 F11 (0.46) F11S1PR1IDO1KLK1CYP1A2
SCHEMBL23466421 0.88 F11 (0.47) F11S1PR1IDO1KLKB1CYP1A2
SCHEMBL29758126 0.88 F11 (0.47) F11S1PR1IDO1KLKB1CYP1A2
SCHEMBL23466422 0.88 F11 (0.47) F11S1PR1IDO1KLKB1CYP1A2
SCHEMBL23486351 0.86 KLKB1 (0.47) F11S1PR1KLKB1KLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114728917-A Oxamide derivative, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2022-07-08 CN disclosed