Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRAS | P01112 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714841 | 1.00 | KMT2A (0.33) | KMT2AMEN1ALDH1A1MAPTHRAS | |
| SCHEMBL15320316 | 0.92 | MET (0.33) | KMT2AMEN1ALDH1A1MAPTHRAS | |
| SCHEMBL29593959 | 0.92 | MET (0.33) | KMT2AMEN1ALDH1A1MAPTHRAS | |
| SCHEMBL16553194 | 0.92 | MET (0.33) | KMT2AMEN1ALDH1A1MAPTHRAS | |
| SCHEMBL29759092 | 0.88 | PKM (0.36) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28696595 | 0.88 | PKM (0.36) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16553000 | 0.87 | KMT2A (0.33) | KMT2AMEN1ALDH1A1MAPTHRAS | |
| SCHEMBL19990061 | 0.85 | MET (0.34) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL19990062 | 0.85 | MET (0.34) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL19990063 | 0.85 | MET (0.34) | KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512851-B1 | BETA-LACTAMASE INHIBITOR COMPOUNDS | ENTASIS THERAPEUTICS LTD (GB) | 2022-07-06 | — | — | EP | disclosed |