Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 5/20 | 0.32 |
| ▸ | JAK1 | P23458 | 5/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27184993 | 1.00 | POLQ (0.35) | POLQGLSTP53MAPTIRAK4 | |
| SCHEMBL24578989 | 0.89 | POLQ (0.37) | POLQCDK9NTRK1KIT | |
| SCHEMBL29759606 | 0.89 | POLQ (0.37) | POLQCDK9NTRK1KIT | |
| SCHEMBL29759976 | 0.87 | POLQ (0.37) | POLQCDK9NTRK1KIT | |
| SCHEMBL27185213 | 0.87 | POLQ (0.37) | POLQCDK9NTRK1KIT | |
| SCHEMBL29759651 | 0.85 | IDO1 (0.36) | GLSTP53MAPTIRAK4GAA | |
| SCHEMBL27185073 | 0.85 | IDO1 (0.36) | GLSTP53MAPTIRAK4GAA | |
| SCHEMBL29760080 | 0.84 | POLQ (0.39) | POLQCDK9NTRK1KIT | |
| SCHEMBL27185204 | 0.84 | POLQ (0.39) | POLQCDK9NTRK1KIT | |
| SCHEMBL29760155 | 0.83 | POLQ (0.37) | POLQNTRK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |