Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185073 | 1.00 | IDO1 (0.36) | IDO1TDO2IRAK4JAK1JAK3 | |
| SCHEMBL27184993 | 0.85 | POLQ (0.35) | IRAK4JAK1GLSTP53MAPT | |
| SCHEMBL29760088 | 0.85 | POLQ (0.35) | IRAK4JAK1GLSTP53MAPT | |
| SCHEMBL29759574 | 0.83 | USP30 (0.40) | IDO1TDO2IRAK4GLSTP53 | |
| SCHEMBL29759955 | 0.83 | USP30 (0.40) | IDO1TDO2IRAK4GLSTP53 | |
| SCHEMBL24579038 | 0.83 | USP30 (0.40) | IDO1TDO2IRAK4GLSTP53 | |
| SCHEMBL24577987 | 0.83 | LCK (0.37) | IRAK4 | |
| SCHEMBL24579053 | 0.81 | KDM1A (0.35) | IRAK4GAA | |
| SCHEMBL29759657 | 0.81 | KDM1A (0.35) | IRAK4GAA | |
| SCHEMBL24577436 | 0.80 | GLS (0.36) | IDO1TDO2IRAK4JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |