Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719102 | 1.00 | ALOX5 (0.56) | ALOX5HSD17B1ESR2TSHRIDO1 | |
| Formic Acid Methyl Ester SCHEMBL30432157 | 0.87 | CYP11B1 (0.46) | ALOX5HSD17B1ESR2IDO1CYP11B1 | |
| Formic Acid Methyl Ester SCHEMBL28432513 | 0.87 | CYP11B1 (0.46) | ALOX5HSD17B1ESR2IDO1CYP11B1 | |
| SCHEMBL30023892 | 0.84 | ALOX5 (0.47) | ALOX5HSD17B1ESR2TSHRIDO1 | |
| SCHEMBL29796762 | 0.84 | IDO1 (0.52) | ALOX5ESR2IDO1CYP11B1CYP11B2 | |
| SCHEMBL30345840 | 0.84 | IDO1 (0.52) | ALOX5ESR2IDO1CYP11B1CYP11B2 | |
| SCHEMBL30957059 | 0.84 | IDO1 (0.52) | ALOX5ESR2IDO1CYP11B1CYP11B2 | |
| SCHEMBL1029061 | 0.80 | TSHR (0.73) | ALOX5HSD17B1ESR2TSHRCYP3A4 | |
| SCHEMBL31226270 | 0.79 | HSD17B1 (0.56) | ALOX5HSD17B1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL1026676 | 0.78 | HSD17B1 (0.55) | ALOX5HSD17B1CYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12478615-B2 | Prolyl hydroxylase inhibitors and methods of use | AKEBIA THERAPEUTICS, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| US-20240358691-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | WARNER CHILCOTT COMPANY, LLC (PR) | 2024-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240358691-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | HIF1AN, EGLN3, EGLN2 | ALOX5 400/4885HSD17B1 1206/4885ESR2 2224/4885 |
| US-12478615-B2 | Prolyl hydroxylase inhibitors and methods of use | HIF1AN, EGLN3, HIF1A | ALOX5 624/4885HSD17B1 862/4885ESR2 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.