Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23275214 | 1.00 | MAPT (0.53) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL14024999 | 0.82 | MAPT (0.56) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29713891 | 0.81 | HRH4 (0.59) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL22468350 | 0.81 | HTT (0.50) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29356740 | 0.81 | HTT (0.50) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL3634340 | 0.81 | HRH4 (0.59) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL20782930 | 0.79 | KMT2A (0.63) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL22121021 | 0.79 | CRHBP (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL245771 | 0.79 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29762483 | 0.79 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114845711-B | Inhibitors of RAF kinase | 皮埃尔法布雷医药公司 | 2024-10-01 | — | — | CN | disclosed |
| EP-4048259-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-08-31 | — | — | EP | disclosed |
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |