Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24628372 | 1.00 | NPY2R (0.52) | NPY2RSMN1; SMN2MAPTGAAMCOLN2 | |
| SCHEMBL29772899 | 0.88 | LIMK2 (0.48) | NPY2RUSP30GPR119LIMK2 | |
| SCHEMBL24628229 | 0.88 | LIMK2 (0.48) | NPY2RUSP30GPR119LIMK2 | |
| SCHEMBL29772864 | 0.86 | MCOLN2 (0.42) | NPY2RMAPTGAAMCOLN2KMT2A | |
| SCHEMBL24628795 | 0.86 | MCOLN2 (0.42) | NPY2RMAPTGAAMCOLN2KMT2A | |
| SCHEMBL30936639 | 0.82 | LIMK2 (0.51) | NPY2RGPR119LIMK2 | |
| SCHEMBL24628788 | 0.81 | MCOLN2 (0.46) | GAAMCOLN2KMT2ACCR5ALDH1A1 | |
| SCHEMBL29772916 | 0.80 | SCN8A (0.52) | MCOLN2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL30936612 | 0.79 | HTR2A (0.50) | GAAMCOLN2KMT2AALDH1A1 | |
| SCHEMBL31720603 | 0.77 | MCOLN2 (0.49) | SMN1; SMN2MAPTMCOLN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150461-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2022-07-14 | — | — | WO | disclosed |