Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772864 | 1.00 | MCOLN2 (0.42) | MCOLN2KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL29772899 | 0.86 | LIMK2 (0.48) | NPY2R | |
| SCHEMBL24628229 | 0.86 | LIMK2 (0.48) | NPY2R | |
| SCHEMBL24628372 | 0.86 | NPY2R (0.52) | MCOLN2KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL29772863 | 0.86 | NPY2R (0.52) | MCOLN2KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL30936639 | 0.80 | LIMK2 (0.51) | NPY2R | |
| SCHEMBL31720818 | 0.80 | LMNA (0.51) | MCOLN2KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL24628788 | 0.79 | MCOLN2 (0.46) | MCOLN2KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL31720602 | 0.79 | LMNA (0.49) | MCOLN2KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL31720603 | 0.78 | MCOLN2 (0.49) | MCOLN2KMT2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150461-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2022-07-14 | — | — | WO | disclosed |