SCHEMBL29773124

SCHEMBL29773124

NC(=O)C1(c2ccc3[nH]ccc3c2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 7/20 0.48
SLC6A4 P31645 7/20 0.48
SLC6A3 Q01959 7/20 0.48
CYP2D6 P10635 6/20 0.48
F2 P00734 1/20 0.45
USP2 O75604 1/20 0.43
GAA P10253 1/20 0.43
ALOX15 P16050 1/20 0.43
RAD51 Q06609 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
LMNA P02545 1/20 0.42
HDAC1 Q13547 1/20 0.41
KCNH2 Q12809 3/20 0.41
CYP2A6 P11509 2/20 0.40
EPHX1 P07099 1/20 0.40
AHR P35869 3/20 0.40
NR4A2 P43354 2/20 0.40
F7 P08709 1/20 0.40
LTA4H P09960 1/20 0.40
F3 P13726 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5114241 1.00 SLC6A2 (0.48) SLC6A2SLC6A4SLC6A3CYP2D6F2
SCHEMBL1465074 0.86 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3CYP2D6USP2
SCHEMBL12742656 0.84 SLC6A2 (0.51) SLC6A2SLC6A4SLC6A3CYP2D6USP2
SCHEMBL1465584 0.81 SLC6A2 (0.48) SLC6A2SLC6A4SLC6A3CYP2D6USP2
SCHEMBL14403866 0.81 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3CYP2D6USP2
SCHEMBL29535017 0.75 HDAC6 (0.45) F2USP2GAAALOX15RAD51
SCHEMBL19753243 0.71 CYP2D6 (0.50) SLC6A2SLC6A4SLC6A3CYP2D6USP2
SCHEMBL7003023 0.71 CYP2D6 (0.50) SLC6A2SLC6A4SLC6A3CYP2D6F2
SCHEMBL13365179 0.71 HDAC1 (0.53) HDAC1EPHX1
Formic Acid SCHEMBL29534961 0.71 HDAC6 (0.41) F2CYP2A6KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332151-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMA (US) 2025-10-30 US claimed
EP-4525858-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS Vertex Pharmaceuticals Incorporated (US) 2025-03-26 EP claimed
EP-4472635-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS Vertex Pharmaceuticals Incorporated (US) 2024-12-11 EP claimed
WO-2023224931-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-11-23 WO claimed
WO-2023150237-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-10 WO claimed
EP-4525858-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS Vertex Pharmaceuticals Incorporated (US) 2025-03-26 EP disclosed
EP-4472635-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS Vertex Pharmaceuticals Incorporated (US) 2024-12-11 EP disclosed
WO-2023224931-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-11-23 WO disclosed
EP-4274828-A1 MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE AbbVie Global Enterprises Ltd. (BM) 2023-11-15 EP disclosed
WO-2023150237-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-10 WO disclosed
WO-2022150174-A1 MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE AbbVie Global Enterprises Ltd. (BM) 2022-07-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250332151-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS CFTR, SLC26A4, SLC26A3 SLC6A2 407/4885SLC6A4 432/4885SLC6A3 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.