Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.71 |
| ▸ | TOP2A | P11388 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RRM2 | P31350 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31237388 | 0.83 | NCOA3 (1.00) | NCOA3NCOA1NPSR1HTTRRM2 | |
| SCHEMBL29773648 | 0.83 | NCOA3 (1.00) | NCOA3NCOA1NPSR1HTTRRM2 | |
| SCHEMBL13927328 | 0.83 | NCOA3 (1.00) | NCOA3NCOA1NPSR1HTTRRM2 | |
| SCHEMBL782069 | 0.83 | NCOA3 (1.00) | NCOA3NCOA1NPSR1HTTRRM2 | |
| SCHEMBL29773626 | 0.83 | NCOA3 (0.70) | NCOA3TOP2ANCOA1NPSR1HTT | |
| SCHEMBL29773611 | 0.83 | NCOA3 (0.70) | NCOA3TOP2ANCOA1NPSR1HTT | |
| SCHEMBL29773615 | 0.82 | NCOA3 (0.49) | NCOA3TOP2AMEN1KMT2ANCOA1 | |
| SCHEMBL29773620 | 0.81 | NCOA3 (0.75) | NCOA3TOP2AMEN1KMT2ANCOA1 | |
| SCHEMBL29773635 | 0.81 | NCOA3 (0.54) | NCOA3TOP2AMEN1KMT2ANCOA1 | |
| SCHEMBL29773628 | 0.81 | NCOA3 (0.54) | NCOA3TOP2AMEN1KMT2ANCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-01-20 | — | — | US | disclosed |
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | TST, TPMT, ABCG2 | NCOA3 408/4885TOP2A 183/4885MEN1 2719/4885 |
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | SCN2B, SCN1B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | NCOA3 412/4885TOP2A 266/4885MEN1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.