Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.70 |
| ▸ | TOP2A | P11388 | 2/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | CTH | P32929 | 3/20 | 0.40 |
| ▸ | RRM2 | P31350 | 2/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29773611 | 1.00 | NCOA3 (0.70) | NCOA3TOP2ANCOA1S100A4CTH | |
| SCHEMBL29773638 | 0.83 | NCOA3 (0.71) | NCOA3TOP2ANCOA1RRM2MAPT | |
| SCHEMBL29773613 | 0.83 | NCOA3 (0.48) | NCOA3TOP2ANCOA1CTHRRM2 | |
| SCHEMBL29773623 | 0.83 | NCOA3 (0.48) | NCOA3TOP2ANCOA1CTHRRM2 | |
| SCHEMBL31237388 | 0.82 | NCOA3 (1.00) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL13927328 | 0.82 | NCOA3 (1.00) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL29773648 | 0.82 | NCOA3 (1.00) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL782069 | 0.82 | NCOA3 (1.00) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL29773614 | 0.79 | TOP2A (0.48) | NCOA3TOP2ANCOA1CTHRRM2 | |
| SCHEMBL29773619 | 0.79 | TOP2A (0.48) | NCOA3TOP2ANCOA1CTHRRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-01-20 | — | — | US | disclosed |
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274929-A1 | THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF | TST, TPMT, ABCG2 | NCOA3 408/4885TOP2A 183/4885NCOA1 803/4885 |
| US-12528774-B2 | Thiosemicarbazone compounds and uses thereof | SCN2B, SCN1B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | NCOA3 412/4885TOP2A 266/4885NCOA1 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.