Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22532771 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL29380591 | 0.88 | KDM4E (0.54) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL22532952 | 0.88 | KDM4E (0.54) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL29774574 | 0.85 | KDM4E (0.51) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL22549630 | 0.83 | MAPT (0.38) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL22532638 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL29774559 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10CASP1CASP7 | |
| SCHEMBL22533363 | 0.81 | ADRA1D (0.49) | ALDH1A1GLAGAAALOX15PARP1 | |
| SCHEMBL22533487 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10GLAGAA | |
| SCHEMBL22533051 | 0.77 | ADRA1D (0.47) | ALDH1A1KDM4EHSD17B10GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230082430-A1 | TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS | C4 THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | US | disclosed |
| US-11407732-B1 | Tricyclic degraders of Ikaros and Aiolos | C4 THERAPEUTICS, INC. (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11407732-B1 | Tricyclic degraders of Ikaros and Aiolos | CRBN, IKZF1, IKZF3 | ALDH1A1 3827/4885KDM4E 315/4885HSD17B10 3566/4885 |
| US-20230082430-A1 | TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS | CRBN, IKZF1, IKZF3 | ALDH1A1 3827/4885KDM4E 315/4885HSD17B10 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.