Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | HPGD | P15428 | 3/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | AURKA | O14965 | 3/20 | 0.75 |
| ▸ | USP2 | O75604 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 13/20 | 0.74 |
| ▸ | TNK2 | Q07912 | 13/20 | 0.74 |
| ▸ | KDR | P35968 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965895 | 0.96 | AURKA (0.81) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2967784 | 0.92 | KDM4E (0.84) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2972462 | 0.91 | KDM4E (0.82) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2976570 | 0.89 | AURKA (0.79) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2971629 | 0.86 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2969946 | 0.85 | LCK (0.92) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2976722 | 0.85 | AURKA (0.76) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2962922 | 0.85 | LCK (0.85) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2971610 | 0.85 | AURKA (0.79) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL2966394 | 0.85 | LCK (1.00) | KDM4EALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776867-B2 | Furanopyrimidines | AMGEN INC. (US) | 2010-08-17 | — | — | US | claimed |
| EP-1768986-A2 | FURANOPYRIMIDINES | Amgen Inc. (US) | 2007-04-04 | — | — | EP | claimed |
| US-20060040961-A1 | Furanopyrimidines | AMGEN INC. | 2006-02-23 | — | — | US | claimed |
| WO-2006004658-A2 | FURANOPYRIMIDINES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | claimed |
| US-7776867-B2 | Furanopyrimidines | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7776867-B2 | Furanopyrimidines | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |
| EP-1768986-A2 | FURANOPYRIMIDINES | Amgen Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006004658-A2 | FURANOPYRIMIDINES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040961-A1 | Furanopyrimidines | TYMS, IDO1, NFATC1 | KDM4E 3284/4885ALDH1A1 159/4885HPGD 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.