Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779038 | 0.89 | TSHR (0.46) | GRK2TSHRHSD17B10USP5KDM5B | |
| SCHEMBL31232321 | 0.89 | TSHR (0.46) | GRK2TSHRHSD17B10USP5KDM5B | |
| SCHEMBL29136029 | 0.88 | TSHR (0.41) | GRK2TSHRUSP5ALDH1A1 | |
| SCHEMBL29778980 | 0.88 | TSHR (0.41) | GRK2TSHRUSP5ALDH1A1 | |
| SCHEMBL29779085 | 0.88 | TSHR (0.41) | GRK2TSHRUSP5ALDH1A1 | |
| SCHEMBL29136033 | 0.88 | TSHR (0.41) | GRK2TSHRUSP5ALDH1A1 | |
| SCHEMBL29136076 | 0.75 | TSHR (0.49) | GRK2TSHRKDM4EHSD17B10USP5 | |
| SCHEMBL30656536 | 0.75 | TSHR (0.49) | GRK2TSHRKDM4EHSD17B10USP5 | |
| SCHEMBL29136078 | 0.75 | TSHR (0.49) | GRK2TSHRKDM4EHSD17B10USP5 | |
| SCHEMBL29779029 | 0.75 | TSHR (0.44) | GRK2TSHRUSP5ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240374582-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF | Genosco Inc. | 2024-11-14 | — | — | US | disclosed |
| US-12064426-B2 | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | Genosco Inc. (US) | 2024-08-20 | — | — | US | disclosed |
| EP-4274825-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| US-20230082993-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. | 2023-03-16 | — | — | US | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12064426-B2 | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | ROCK2, ROCK1, MYLK3 | GRK2 182/4885TSHR 4083/4885MAPK1 134/4885 |
| US-20230082993-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | ROCK2, ROCK1, MYLK3 | GRK2 182/4885TSHR 4083/4885MAPK1 134/4885 |
| US-20240374582-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF | ROCK2, ROCK1, MYLK3 | GRK2 216/4885TSHR 4258/4885MAPK1 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.