Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554584 | 1.00 | ADORA2A (0.43) | ADORA2AADORA1JAK2JAK3TRPM8 | |
| SCHEMBL19554618 | 0.88 | MAPT (0.47) | ADORA2AADORA1NPC1RAB9AMAPT | |
| SCHEMBL29779687 | 0.86 | ALDH1A1 (0.46) | ADORA2AADORA1NPC1RAB9AMAPT | |
| SCHEMBL19554631 | 0.86 | ALDH1A1 (0.46) | ADORA2AADORA1NPC1RAB9AMAPT | |
| SCHEMBL19554641 | 0.76 | NPC1 (0.44) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL25780269 | 0.75 | EPHX2 (0.49) | RAB9AMAPTKDM4EALDH1A1GAA | |
| SCHEMBL19554582 | 0.75 | TRPM8 (0.41) | JAK2JAK3TRPM8MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL19554597 | 0.71 | TAAR1 (0.45) | ADORA2AADORA1MAPTKDM4EGAA | |
| SCHEMBL23985276 | 0.68 | MAPT (0.43) | ADORA2ANPC1RAB9AMAPTPTPN1 | |
| SCHEMBL30450539 | 0.68 | MAPT (0.43) | ADORA2ANPC1RAB9AMAPTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311902-B | Substituted imidazo [1,2-b ] pyridazines, imidazo [1,5-b ] pyridazines, related compounds, and uses thereof | BIAL研发投资股份有限公司 | 2022-07-15 | — | — | CN | disclosed |