Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371289 | 0.73 | GAA (0.65) | GAAMEN1POLBBLMUBE2N | |
| SCHEMBL31154260 | 0.70 | GAA (0.49) | GAAMEN1POLBBLMUBE2N | |
| SCHEMBL29941412 | 0.68 | NPC1 (0.62) | GAAPOLBMETAP2KDM4ENPC1 | |
| SCHEMBL546102 | 0.68 | NPC1 (0.62) | GAAPOLBMETAP2KDM4ENPC1 | |
| SCHEMBL4842304 | 0.68 | DYRK1A (0.37) | KDM4ELMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL4235899 | 0.67 | MEN1 (0.30) | MEN1KMT2ALMNAADORA1 | |
| SCHEMBL5578315 | 0.67 | — | — | |
| SCHEMBL28385965 | 0.66 | BACE1 (0.44) | PLAU | |
| SCHEMBL17336302 | 0.64 | ALDH1A1 (0.61) | GAAKDM4ENPC1LMNAMAPT | |
| SCHEMBL13733893 | 0.64 | KDM4E (0.37) | KDM4ENPC1RAB9AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761013-A | Methods of treating myelofibrosis and related disorders | 迪斯克医药公司 | 2022-07-15 | — | — | CN | disclosed |