Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.38 |
| ▸ | KDR | P35968 | 9/20 | 0.38 |
| ▸ | ABL1 | P00519 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 8/20 | 0.38 |
| ▸ | HCK | P08631 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 8/20 | 0.38 |
| ▸ | MTOR | P42345 | 8/20 | 0.38 |
| ▸ | PRKDC | P78527 | 8/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.38 |
| ▸ | BTK | Q06187 | 8/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30136522 | 0.82 | KDR (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL30513345 | 0.80 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL30569291 | 0.68 | SRC (0.60) | KDRABL1EGFRSRCBTK | |
| SCHEMBL29780932 | 0.66 | EGFR (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL30569231 | 0.66 | SRC (0.48) | KDRABL1EGFRSRCBTK | |
| SCHEMBL28656676 | 0.66 | SRC (0.48) | KDRABL1EGFRSRCBTK | |
| SCHEMBL28658740 | 0.62 | SRC (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL30569241 | 0.62 | SRC (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL23997323 | 0.62 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGKDR | |
| SCHEMBL24096492 | 0.62 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |