Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.37 |
| ▸ | PRKDC | P78527 | 14/20 | 0.37 |
| ▸ | ABL1 | P00519 | 13/20 | 0.37 |
| ▸ | EGFR | P00533 | 13/20 | 0.37 |
| ▸ | HCK | P08631 | 13/20 | 0.37 |
| ▸ | SRC | P12931 | 13/20 | 0.37 |
| ▸ | MTOR | P42345 | 13/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 13/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.32 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780867 | 0.82 | PIK3CD (0.38) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29780932 | 0.82 | EGFR (0.42) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23997323 | 0.77 | PIK3CD (0.58) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1319000 | 0.68 | KDR (0.71) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29781046 | 0.68 | PIK3CD (0.39) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24096496 | 0.65 | PIK3CD (0.61) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23997146 | 0.64 | BTK (0.65) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24096491 | 0.64 | PIK3CD (0.52) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30782437 | 0.63 | ABL1 (0.53) | ABL1EGFR | |
| SCHEMBL1317659 | 0.63 | LCK (0.73) | KDRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023016296-A1 | HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2023-02-16 | — | — | WO | disclosed |