Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.33 |
| ▸ | PRKDC | P78527 | 15/20 | 0.33 |
| ▸ | ABL1 | P00519 | 14/20 | 0.33 |
| ▸ | HCK | P08631 | 14/20 | 0.33 |
| ▸ | SRC | P12931 | 14/20 | 0.33 |
| ▸ | KDR | P35968 | 14/20 | 0.33 |
| ▸ | MTOR | P42345 | 14/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.33 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.32 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30136522 | 0.82 | KDR (0.37) | EGFRMERTKBTKLCKLYN | |
| SCHEMBL30513264 | 0.80 | EGFR (0.59) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL29780934 | 0.71 | EGFR (0.37) | EGFRBTKLCKPIK3CDPIK3CA | |
| SCHEMBL16752366 | 0.70 | CDC7 (0.36) | EGFRLCKPIK3CDPIK3CASRC | |
| SCHEMBL5805229 | 0.69 | BTK (0.75) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL5823929 | 0.67 | BTK (0.61) | EGFRBTKLCKLYNPIK3CD | |
| SCHEMBL29780867 | 0.66 | PIK3CD (0.38) | EGFRBTKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL22720779 | 0.65 | BTK (0.70) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL29439195 | 0.65 | BTK (0.70) | EGFRBTKLCKLYNABL1 | |
| SCHEMBL24096496 | 0.65 | PIK3CD (0.61) | EGFRBTKLCKLYNPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |