Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 5/20 | 0.45 |
| ▸ | SRC | P12931 | 6/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052158 | 1.00 | ADK (0.45) | ADKSRCLCKDYRK1ADYRK3 | |
| SCHEMBL29781101 | 0.81 | ADK (0.41) | ADKSRC | |
| SCHEMBL29052179 | 0.81 | ADK (0.41) | ADKSRC | |
| SCHEMBL16236958 | 0.81 | DYRK3 (0.60) | ADKSRCLCKDYRK1ADYRK3 | |
| SCHEMBL869273 | 0.81 | SRC (0.46) | ADKSRCLCKDYRK1ADYRK3 | |
| SCHEMBL868932 | 0.81 | FLT3 (0.42) | ADKSRCLCKDYRK1AFLT3 | |
| SCHEMBL29781089 | 0.80 | DYRK1A (0.46) | ADKSRCDYRK1ADYRK3ROCK2 | |
| SCHEMBL29780942 | 0.80 | ADK (0.41) | ADKSRCDYRK1ADYRK3ROCK2 | |
| SCHEMBL18658332 | 0.80 | DYRK1A (0.46) | ADKSRCDYRK1ADYRK3ROCK2 | |
| SCHEMBL870030 | 0.77 | METTL3 (0.52) | ADKFLT3METTL3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |