Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30513350 | 0.73 | JAK2 (0.54) | EGFRRETMAPK1CDC7PLK4 | |
| SCHEMBL29617723 | 0.73 | RET (0.64) | EGFRRETMAPK1CDC7PLK4 | |
| SCHEMBL5814550 | 0.73 | JAK2 (0.54) | EGFRRETMAPK1CDC7PLK4 | |
| SCHEMBL5805110 | 0.73 | RET (0.64) | EGFRRETMAPK1CDC7PLK4 | |
| SCHEMBL29780932 | 0.71 | EGFR (0.42) | EGFRBTKLCKSRCKDR | |
| SCHEMBL23847697 | 0.71 | ADK (0.48) | EGFRRETMAP4K4LCKFYN | |
| SCHEMBL1443714 | 0.71 | ADK (0.54) | EGFRRAB9ARETMAP4K4LCK | |
| SCHEMBL30563711 | 0.71 | EGFR (0.38) | EGFRBTKRETMAPK1CDC7 | |
| SCHEMBL29886844 | 0.70 | EGFR (0.50) | EGFRBTKALDH1A1RETLCK | |
| SCHEMBL20744975 | 0.70 | EGFR (0.55) | EGFRBTKALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |