Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185757 | 1.00 | STING1 (0.42) | STING1KDM4AGRM2ATRCACNA1H | |
| SCHEMBL29784449 | 0.88 | ESR2 (0.40) | STING1KDM4AATRCACNA1HCACNA1B | |
| SCHEMBL27185785 | 0.88 | ALDH1A1 (0.40) | STING1KDM4AATRCACNA1HCACNA1B | |
| SCHEMBL29784510 | 0.88 | ALDH1A1 (0.40) | STING1KDM4AATRCACNA1HCACNA1B | |
| SCHEMBL27185758 | 0.88 | ESR2 (0.40) | STING1KDM4AATRCACNA1HCACNA1B | |
| SCHEMBL29784315 | 0.87 | SLC22A12 (0.44) | STING1KDM4AATRKDM4EALDH1A1 | |
| SCHEMBL29784436 | 0.87 | STING1 (0.38) | STING1KDM4AGRM2CACNA1HCACNA1B | |
| SCHEMBL16347843 | 0.87 | STING1 (0.38) | STING1KDM4AATRCACNA1HCACNA1B | |
| SCHEMBL29784337 | 0.87 | STING1 (0.43) | STING1KDM4AATRALDH1A1GAA | |
| SCHEMBL27185593 | 0.87 | STING1 (0.43) | STING1KDM4AATRALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169921-A1 | BENZOFURAN COMPOUNDS AS STING AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-11 | — | — | WO | disclosed |