Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SORD | Q00796 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926549 | 0.81 | LMNA (0.54) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL23698063 | 0.80 | MGLL (0.63) | MGLLLMNASMN1; SMN2HTTNAAA | |
| SCHEMBL31473673 | 0.79 | LMNA (0.57) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL22657643 | 0.78 | CHRNA7 (0.51) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL12506010 | 0.77 | LMNA (0.60) | MGLLLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL13810054 | 0.77 | LMNA (0.56) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL29784238 | 0.77 | MGLL (0.54) | MGLLLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL30937143 | 0.74 | HCRTR1 (0.52) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL2040215 | 0.74 | LMNA (0.66) | LMNASMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL2603212 | 0.74 | LMNA (0.58) | LMNASMN1; SMN2HTTMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | MGLL 10/4885LMNA 1960/4885SMN1; SMN2 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.