Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 11/20 | 1.00 |
| ▸ | HSD17B2 | P37059 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.54 |
| ▸ | CLK1 | P49759 | 2/20 | 0.54 |
| ▸ | SNCA | P37840 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8400538 | 0.90 | HSD17B1 (0.81) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8400518 | 0.89 | HSD17B1 (0.80) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8404891 | 0.89 | HSD17B1 (0.80) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8400513 | 0.89 | HSD17B1 (0.80) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31407 | 0.88 | HSD17B1 (0.79) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30049 | 0.86 | HSD17B1 (0.76) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8401031 | 0.86 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8405370 | 0.86 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8401401 | 0.85 | HSD17B1 (0.73) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8402862 | 0.81 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| CN-1063443-C | Novel benzothiazole derivatives | NIPPON INTERNAL ORGANS PHARMAC (JP) | 2001-03-21 | — | — | CN | disclosed |
| US-5900426-A | ANTILIPEMIC AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1999-05-04 | — | — | US | disclosed |
| EP-0735029-B1 | Benzothiazole derivatives | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1998-06-03 | — | — | EP | disclosed |
| CN-1137524-A | Novel benzothiazole derivatives | NIPPON INTERNAL ORGANS PHARMAC (JP) | 1996-12-11 | — | — | CN | disclosed |
| EP-0735029-A1 | Benzothiazole derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-10-02 | — | — | EP | disclosed |