Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 8/20 | 0.79 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.79 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29786 | 0.88 | HSD17B1 (1.00) | HSD17B1HSD17B2DYRK1ACYP1A2CYP3A4 | |
| SCHEMBL24751 | 0.84 | HSD17B1 (0.62) | HSD17B1HSD17B2LMNATP53NFKB1 | |
| SCHEMBL900711 | 0.84 | SCD (0.62) | HSD17B1HSD17B2FAAHCYP1A2CYP3A4 | |
| SCHEMBL27623260 | 0.84 | HSD17B1 (0.67) | HSD17B1HSD17B2FAAHCYP1A2CYP3A4 | |
| SCHEMBL1304947 | 0.83 | HSD17B1 (0.66) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL28862925 | 0.83 | HSD17B1 (0.61) | HSD17B1HSD17B2LMNATP53NFKB1 | |
| SCHEMBL31078 | 0.81 | RAB9A (0.65) | HSD17B1HSD17B2FAAHLMNATP53 | |
| SCHEMBL8400538 | 0.81 | HSD17B1 (0.81) | HSD17B1HSD17B2DYRK1ACYP1A2CYP3A4 | |
| SCHEMBL6319718 | 0.81 | ALDH1A1 (0.66) | HSD17B1HSD17B2DYRK1ALMNATP53 | |
| SCHEMBL8405370 | 0.80 | HSD17B1 (0.74) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2008129129-A1 | HETEROCYCLIC PHENYL CARBAMATES AS NOVEL FAAH-INHIBITORS | KUOPION YLIOPISTO (FI) | 2008-10-30 | — | — | WO | disclosed |