SCHEMBL29786205

SCHEMBL29786205

CNC(=O)c1cnn2cc(-c3cnn(C)c3)ccc12

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 2/20 0.60
CLK1 P49759 1/20 0.54
HAT1 O14929 10/20 0.48
EP300 Q09472 10/20 0.48
CHRM1 P11229 1/20 0.47
PDGFRA P16234 1/20 0.47
HRH3 Q9Y5N1 1/20 0.47
PIK3CG P48736 1/20 0.47
CCNC P24863 3/20 0.46
CDK8 P49336 3/20 0.46
CREBBP Q92793 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17454467 0.86 USP30 (0.55) USP30CLK1HAT1EP300CHRM1
SCHEMBL30363245 0.85 USP30 (0.54) USP30CLK1HAT1EP300CHRM1
SCHEMBL30998745 0.84 USP30 (0.54) USP30CLK1HAT1EP300CHRM1
SCHEMBL29786187 0.84 HAT1 (0.54) USP30HAT1EP300PIK3CGCCNC
Lithium Ion SCHEMBL31293538 0.83 USP30 (0.53) USP30CLK1HAT1EP300CHRM1
SCHEMBL17452701 0.82 HAT1 (0.54) USP30CLK1HAT1EP300CHRM1
SCHEMBL20229576 0.82 USP30 (0.52) USP30CLK1HAT1EP300CHRM1
SCHEMBL31212715 0.79 USP30 (0.49) USP30HAT1EP300CHRM1PDGFRA
SCHEMBL23501220 0.77 CLK1 (0.46) USP30CLK1PIK3CGCCNCCDK8
SCHEMBL14743393 0.77 PDGFRA (0.67) USP30HAT1EP300CHRM1PDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120051471-A Novel heterocyclic compound 首药控股(北京)股份有限公司 2025-05-27 CN disclosed
CN-112939967-B Pyrazolo [1,5-a ] pyridine compound, and preparation method and application thereof 深圳众格生物科技有限公司 2024-08-27 CN disclosed
CN-114787161-B Pyrazolo [1,5-a ] pyridine compound, and preparation method and application thereof 深圳众格生物科技有限公司 2024-08-02 CN disclosed
CN-114787161-A Pyrazolo [1,5-a ] pyridine compound and preparation method and application thereof 深圳众格生物科技有限公司 2022-07-22 CN disclosed