Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123907 | 1.00 | KDM4C (0.48) | KDM4CKDM5BGSK3BCDK5CDK5R1 | |
| SCHEMBL23124130 | 0.80 | CDK5 (0.48) | KDM4CKDM5BCDK5CDK5R1CYP19A1 | |
| SCHEMBL29786263 | 0.80 | CDK5 (0.48) | KDM4CKDM5BCDK5CDK5R1CYP19A1 | |
| SCHEMBL5761329 | 0.77 | CYP11B1 (0.54) | KDM4CKDM5BCDK5CDK5R1MAPT | |
| SCHEMBL4840104 | 0.77 | HPGDS (0.58) | KDM4CKDM5BCDK5CDK5R1MAPT | |
| SCHEMBL20232778 | 0.74 | KDM4C (0.43) | KDM4CKDM5BCDK5CDK5R1CYP19A1 | |
| SCHEMBL5755079 | 0.74 | NPC1 (0.60) | CDK5CDK5R1CYP19A1MAPTCYP2E1 | |
| SCHEMBL23123889 | 0.73 | ELANE (0.49) | — | |
| SCHEMBL29786345 | 0.73 | ELANE (0.49) | — | |
| SCHEMBL5757721 | 0.73 | CLK1 (0.50) | KDM4CKDM5BCDK5CDK5R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031531-A1 | SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | Bial-R&D Investments, S.A. (PT) | 2022-07-27 | — | — | EP | disclosed |
| CN-114787135-A | Substituted imidazole carboxamides and their use in the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-07-22 | — | — | CN | disclosed |