Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123816 | 1.00 | LMNA (0.50) | LMNAMAPTALDH1A1NR3C2HTT | |
| SCHEMBL28059309 | 0.88 | MAPT (0.54) | LMNAMAPTALDH1A1NR3C2KDM4E | |
| SCHEMBL1546436 | 0.85 | ALDH1A1 (0.61) | LMNAMAPTALDH1A1SMN1; SMN2RORC | |
| SCHEMBL521740 | 0.82 | LMNA (0.50) | LMNAMAPTALDH1A1NR3C2HTT | |
| SCHEMBL29051883 | 0.82 | MAPT (0.52) | LMNAMAPTALDH1A1NR3C2ALOX5 | |
| SCHEMBL23124107 | 0.82 | LMNA (0.54) | LMNAALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL30796099 | 0.81 | JAK2 (0.48) | LMNAMAPTALDH1A1NR3C2ALOX5 | |
| SCHEMBL25447137 | 0.81 | MAPT (0.51) | LMNAMAPTALDH1A1ALOX5NPC1 | |
| SCHEMBL30376728 | 0.81 | MAPT (0.51) | LMNAMAPTALDH1A1ALOX5NPC1 | |
| SCHEMBL17443259 | 0.81 | ALDH1A1 (0.48) | LMNAMAPTALDH1A1NR3C2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901652-A | Substituted saturated and unsaturated N-heterocyclic carboxamides and related compounds for the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114787135-A | Substituted imidazole carboxamides and their use in the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-07-22 | — | — | CN | disclosed |