SCHEMBL29787341

SCHEMBL29787341

CCc1onc(-c2ccccc2)c1CC

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.69
PTGS1 P23219 2/20 0.69
CYP1A1 P04798 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2E1 P05181 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2A6 P11509 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP4B1 P13584 1/20 0.46
CYP2B6 P20813 1/20 0.46
CYP3A5 P20815 1/20 0.46
CYP2A7 P20853 1/20 0.46
CYP3A7 P24462 1/20 0.46
CYP2F1 P24903 1/20 0.46
CYP2C18 P33260 1/20 0.46
CYP2C19 P33261 1/20 0.46
CYP2J2 P51589 1/20 0.46
CYP4F2 P78329 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526143 0.88 PTGS2 (0.63) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL4974872 0.84 PTGS2 (0.58) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL27749854 0.84 PTGS2 (0.58) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL2279510 0.81 PTGS2 (1.00) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL10078260 0.81 PTGS2 (0.69) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL256699 0.81 PTGS1 (0.59) PTGS2PTGS1GABRA5ALDH1A1NPSR1
SCHEMBL7375447 0.80 PTGS1 (0.46) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL12088074 0.80 PTGS2 (0.67) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL2473730 0.76 PTGS1 (0.61) PTGS2PTGS1CYP1A1CYP1A2CYP2E1
SCHEMBL5729456 0.75 PTGS2 (0.44) PTGS2PTGS1CYP1A2CYP2C19GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114773284-A Synthesis method of visible light mediated dihydroisoxazole 河南大学 2022-07-22 CN disclosed