Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 6/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.46 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.46 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.46 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13524347 | 0.85 | PTGS2 (0.73) | PTGS2PTGS1CYP3A4CA12MT-CO2 | |
| SCHEMBL4880685 | 0.84 | PTGS2 (0.77) | PTGS2PTGS1CYP3A4CA12MT-CO2 | |
| SCHEMBL28096745 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1PDE3ACYP3A4CA12 | |
| SCHEMBL13981827 | 0.81 | PTGS1 (0.69) | PTGS2PTGS1LMNA | |
| SCHEMBL29787341 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL10078260 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL8802159 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1PDE3ACYP3A4CA12 | |
| SCHEMBL8802163 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1PDE3ACYP3A4CA12 | |
| SCHEMBL12088074 | 0.80 | PTGS2 (0.67) | PTGS2PTGS1CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL13241360 | 0.80 | PTGS2 (0.75) | PTGS2PTGS1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246337-B1 | Isoxazole derivatives for use as cyclooxygenase inhibitors | UNIV BARI (IT) | 2011-12-21 | — | — | EP | claimed |
| EP-2246337-A1 | Use of isoxazole derivatives as cyclooxygenase inhibitors | Universita' degli Studi di Bari (IT) | 2010-11-03 | — | — | EP | claimed |
| EP-2246337-B1 | Isoxazole derivatives for use as cyclooxygenase inhibitors | UNIV BARI (IT) | 2011-12-21 | — | — | EP | disclosed |
| US-7989450-B2 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-08-02 | — | — | US | disclosed |
| EP-2246337-A1 | Use of isoxazole derivatives as cyclooxygenase inhibitors | Universita' degli Studi di Bari (IT) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246337-A1 | Use of isoxazole derivatives as cyclooxygenase inhibitors | Universita' degli Studi di Bari (IT) | 2010-11-03 | — | — | EP | disclosed |
| EP-1706390-B1 | ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS | UNIV BARI (IT) | 2010-05-19 | — | — | EP | disclosed |
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2009-07-16 | — | — | US | disclosed |
| EP-1706390-A2 | ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS | Universita' degli studi di Bari (IT) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005123701-A1 | METHOD FOR THE PREPARATION OF DIARYLISOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES | PHARMACIA CORPORATION (US) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005068442-A2 | ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS | UNIVERSITA DEGLI STUDI DI BARI (IT) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | PTGIS, ALOX5, ALOX15 | PTGS2 12/4885PTGS1 4/4885PDE3A 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.