Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29585645 | 0.83 | NNMT (0.68) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL29683986 | 0.82 | NNMT (0.62) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL11551255 | 0.82 | NNMT (0.62) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL23834721 | 0.82 | NNMT (0.62) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL1680864 | 0.81 | NNMT (0.61) | NNMTMKNK1MKNK2MAPTSMN1; SMN2 | |
| SCHEMBL2817347 | 0.80 | MAPT (0.72) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL6953681 | 0.80 | NNMT (0.59) | NNMTMKNK1MKNK2MAPTOPRM1 | |
| Hydrochloric Acid SCHEMBL5010367 | 0.79 | MAPT (0.70) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL30969236 | 0.78 | NNMT (0.56) | NNMTMKNK1MKNK2MAPTGABRA1 | |
| SCHEMBL29975550 | 0.76 | NNMT (1.00) | NNMTMKNK1MKNK2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423451-B1 | INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | PROPELLON THERAPEUTICS INC (CA) | 2022-08-17 | — | — | EP | disclosed |
| CN-109195965-B | Inhibitors of WDR5 protein-protein binding | 普罗佩纶治疗公司 | 2022-07-26 | — | — | CN | disclosed |