Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981055 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6 | |
| SCHEMBL2969790 | 0.77 | TRPV1 (0.50) | HDAC1KDM4EHDAC6 | |
| SCHEMBL2979003 | 0.77 | RBP4 (0.41) | HDAC1KMT2AMTHFD2MEN1 | |
| SCHEMBL2969834 | 0.77 | HTR5A (0.44) | HDAC1KMT2ANPC1RAB9AOGA | |
| SCHEMBL2972415 | 0.77 | KMT2A (0.40) | KMT2ANPC1RAB9AOGAKDM4E | |
| SCHEMBL2978467 | 0.73 | HDAC1 (0.47) | HDAC1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2978160 | 0.72 | HDAC1 (0.53) | HDAC1ALDH1A1HDAC6 | |
| SCHEMBL2971545 | 0.71 | HDAC1 (0.40) | HDAC1KMT2ANPC1RAB9AOGA | |
| SCHEMBL6013769 | 0.69 | SCN9A (0.37) | HDAC1KMT2ANPC1RAB9AOGA | |
| SCHEMBL2970402 | 0.69 | BAZ2B (0.47) | HDAC1KMT2ANPC1OGAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772245-B2 | Inhibitors of histone deacetylase | MIIKANA THERAPEUTICS, INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20060199829-A1 | Inhibitors of histone deacetylase | MIIKANA THERAPEUTICS, INC. | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199829-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC2, HDAC11 | HDAC1 1/4885KMT2A 82/4885NPC1 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.