Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21405035 | 1.00 | OPRM1 (0.41) | OPRM1DDB1CRBNROCK2ROCK1 | |
| SCHEMBL21456184 | 0.89 | OPRM1 (0.46) | OPRM1ROCK2ROCK1HTR2AHTR2C | |
| SCHEMBL21405149 | 0.82 | OPRM1 (0.42) | OPRM1ROCK2ROCK1 | |
| SCHEMBL29838276 | 0.82 | OPRM1 (0.42) | OPRM1ROCK2ROCK1 | |
| SCHEMBL21456466 | 0.80 | KDM4C (0.43) | OPRM1HTR2AHTR2CHTR2B | |
| SCHEMBL29790364 | 0.75 | SMARCA2 (0.46) | — | |
| SCHEMBL21405098 | 0.75 | SMARCA2 (0.46) | — | |
| SCHEMBL23205339 | 0.73 | OPRM1 (0.47) | OPRM1ROCK2HTR2AHTR2CHTR2B | |
| SCHEMBL21673432 | 0.71 | HRH3 (0.36) | OPRM1HTR2A | |
| SCHEMBL23205341 | 0.69 | OPRM1 (0.50) | OPRM1ROCK2ROCK1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4038066-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114787159-A | BRM targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2022-07-22 | — | — | CN | disclosed |