Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.54 |
| ▸ | CBFB | Q13951 | 1/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 10/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TCF4 | P15884 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977718 | 0.81 | AMY1A (0.56) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL2978439 | 0.77 | CBFB (0.80) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL28487873 | 0.76 | AMY1A (0.68) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL28477377 | 0.72 | CYP11B1 (0.70) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL6158996 | 0.72 | KDR (0.74) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL5118616 | 0.72 | CDK1 (0.77) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL2315219 | 0.71 | AMY1A (0.57) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL13658385 | 0.71 | AMY1A (0.57) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| Hydrochloric Acid SCHEMBL5119587 | 0.71 | CDK1 (0.75) | METAP2METAP1CBFBAMY1ACYP11B1 | |
| SCHEMBL28492593 | 0.71 | KDR (0.58) | AMY1AKDRMETNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2005002503-A2 | ASYMMETRIC BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNJ1, KCNJ11 | METAP2 3453/4885METAP1 4171/4885CBFB 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.