Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315219 | 0.79 | AMY1A (0.57) | AMY1AALDH1A1NPC1RAB9AMETAP2 | |
| SCHEMBL13437185 | 0.79 | AMY1A (0.51) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2314913 | 0.79 | AMY1A (0.51) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4760730 | 0.78 | AMY1A (0.53) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2317508 | 0.77 | AMY1A (0.55) | AMY1AALDH1A1NPC1RAB9AMETAP2 | |
| SCHEMBL2317512 | 0.77 | AMY1A (0.55) | AMY1AALDH1A1NPC1RAB9AMETAP2 | |
| SCHEMBL3200890 | 0.76 | MAPT (0.72) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL18311587 | 0.73 | RAB9A (0.67) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2977718 | 0.73 | AMY1A (0.56) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2946648 | 0.72 | NPC1 (0.70) | AMY1AALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |