Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 15/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21356631 | 1.00 | KDM4E (0.38) | KDM4EMAPK1USP7HRH1HRH4 | |
| SCHEMBL21355171 | 0.82 | NOS3 (0.38) | KDM4EMAPK1HRH1HRH4HRH3 | |
| SCHEMBL29127205 | 0.80 | KDM4E (0.39) | KDM4E | |
| SCHEMBL3923713 | 0.78 | LMNA (0.42) | KDM4EMAPK1HRH1HRH4HRH3 | |
| SCHEMBL24738192 | 0.78 | MAPK1 (0.36) | KDM4EMAPK1 | |
| SCHEMBL21356126 | 0.78 | PLAU (0.38) | KDM4EMAPK1 | |
| SCHEMBL24738195 | 0.76 | KDM4E (0.34) | KDM4EMAPK1 | |
| SCHEMBL14192011 | 0.75 | SSTR5 (0.41) | KDM4E | |
| SCHEMBL21712544 | 0.72 | KDM4E (0.38) | KDM4EMAPK1USP7HRH1HRH4 | |
| SCHEMBL14934977 | 0.72 | KDM4E (0.38) | KDM4EMAPK1HRH1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| EP-4031547-A1 | PLASMA KALLIKREIN INHIBITORS AND USES THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2022-07-27 | — | — | EP | disclosed |