Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29793121 | 0.98 | CA12 (0.46) | CA12CA9F11HPGDCA1 | |
| SCHEMBL28426600 | 0.76 | CA12 (0.37) | CA12HPGDMAPK1ARKDR | |
| SCHEMBL4282655 | 0.74 | CA12 (0.47) | CA12CA9F11HPGDCA1 | |
| SCHEMBL16670417 | 0.73 | PDE3B (0.39) | HPGDPDE3BPDE3AMAPK1PDE4A | |
| SCHEMBL4173625 | 0.73 | CYP1A2 (0.50) | CA12HPGDARMAPT | |
| SCHEMBL13680450 | 0.73 | CA12 (0.53) | CA12CA9F11HPGDCA1 | |
| SCHEMBL4287747 | 0.72 | PDE3B (0.57) | CA12CA9F11CA1CA3 | |
| SCHEMBL17505162 | 0.72 | CA12 (0.51) | CA12CA9F11HPGDCA1 | |
| SCHEMBL15345000 | 0.72 | CA12 (0.59) | CA12CA9F11HPGDCA1 | |
| SCHEMBL4552802 | 0.71 | CA12 (0.57) | CA12CA9F11HPGDCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896063-B1 | CRYSTALLINE FORMS OF THE SYK INHIBITOR 5-FLUORO-1-METHYL-3-[[5-[4-(3-OXETANYL)-1-PIPERAZINYL]-2-PYRIDINYL]AMINO]-6-(1H-PYRAZOL-3-YL)-2(1H)-QUINOLINONE HYDROCHLORIDE SALT (1:1) | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2024-01-24 | — | — | EP | disclosed |
| CN-113166106-B | Salt of Syk inhibitor and crystal form thereof | 正大天晴药业集团股份有限公司 | 2022-07-08 | — | — | CN | disclosed |