Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16766999 | 0.76 | LMNA (0.36) | PDE3BPDE3ALMNAMAPTMEN1 | |
| SCHEMBL29793162 | 0.73 | CA12 (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL29793121 | 0.72 | CA12 (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL15850229 | 0.72 | AURKB (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8486152 | 0.71 | LMNA (0.35) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL28065851 | 0.71 | CYP1A2 (0.35) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28029443 | 0.69 | AKT2 (0.54) | MAPTCHEK1MAPK1 | |
| SCHEMBL28313237 | 0.69 | — | — | |
| SCHEMBL17608417 | 0.69 | MAP4K4 (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL5468496 | 0.69 | IDO1 (0.37) | MAPTL3MBTL1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060046-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | Dow AgroSciences LLC (US) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061161-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | DOW AGROSCIENCES LLC (US) | 2015-04-30 | — | — | WO | disclosed |
| CN-102405219-B | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of COPD | ASTRAZENECA AB | 2013-11-06 | — | — | CN | disclosed |
| CN-102405219-B | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of COPD | ASTRAZENECA AB | 2013-11-06 | — | — | CN | disclosed |
| CN-102405219-A | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd | ASTRAZENECA AB | 2012-04-04 | — | — | CN | disclosed |
| CN-102405219-A | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd | ASTRAZENECA AB | 2012-04-04 | — | — | CN | disclosed |