Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.35 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29793698 | 0.90 | WNK1 (0.41) | WNK1HSD11B1TP53DHFRRXFP1 | |
| SCHEMBL10924129 | 0.85 | MAPK1 (0.41) | WNK1HSD11B1TP53DHFRALDH1A1 | |
| SCHEMBL3037513 | 0.85 | KMT2A (0.40) | WNK1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3036505 | 0.85 | KMT2A (0.47) | HSD11B1TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL20240595 | 0.82 | NPC1 (0.44) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL16782293 | 0.82 | MAPT (0.41) | WNK1HSD11B1DHFRALDH1A1MEN1 | |
| SCHEMBL5346439 | 0.82 | ATM (0.42) | WNK1HSD11B1TP53DHFRALDH1A1 | |
| SCHEMBL20520337 | 0.80 | HPGD (0.39) | WNK1HSD11B1TP53DHFRALDH1A1 | |
| SCHEMBL23092182 | 0.79 | BCL6 (0.40) | ALDH1A1CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL4095108 | 0.78 | HTT (0.44) | CYP2D6MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775277-A | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-114793435-B | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-115103844-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of e.g. autoimmune diseases | 原真股份有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-114793435-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1, and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2022-07-26 | — | — | CN | disclosed |