Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20240595 | 0.90 | NPC1 (0.44) | KMT2ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL3037513 | 0.85 | KMT2A (0.40) | KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL10924129 | 0.85 | MAPK1 (0.41) | KMT2ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL29793554 | 0.85 | WNK1 (0.39) | KMT2AALDH1A1GAAMAPTHSD11B1 | |
| SCHEMBL5346439 | 0.82 | ATM (0.42) | KMT2AALDH1A1CYP3A4MAPTTDP1 | |
| SCHEMBL29793698 | 0.82 | WNK1 (0.41) | KMT2AALDH1A1MAPTHSD11B1TP53 | |
| SCHEMBL16782293 | 0.82 | MAPT (0.41) | KMT2AALDH1A1MAPTHSD11B1 | |
| SCHEMBL30143533 | 0.82 | KMT2A (0.41) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL17978448 | 0.81 | ALDH1A1 (0.50) | KMT2ANPC1RAB9AALDH1A1TSHR | |
| SCHEMBL20520337 | 0.80 | HPGD (0.39) | KMT2AALDH1A1CYP3A4MAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536571-B | Preparation method of indole derivative | 上海裕兰生物科技有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115536571-A | Preparation method of indole derivative | 上海裕兰生物科技有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2010-08-26 | — | — | US | disclosed |
| EP-1910369-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007013673-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | LCK, ZAP70, FYN | KMT2A 547/4885NPC1 4572/4885RAB9A 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.