Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394775 | 1.00 | BRD4 (0.68) | BRD4EGFR | |
| SCHEMBL30620422 | 0.92 | EGFR (0.68) | BRD4EGFR | |
| SCHEMBL270435 | 0.85 | BRD4 (0.76) | BRD4EGFR | |
| Hydrochloric Acid SCHEMBL266755 | 0.84 | BRD4 (0.74) | BRD4EGFR | |
| SCHEMBL271488 | 0.82 | BRD4 (0.80) | BRD4EGFR | |
| SCHEMBL17915974 | 0.82 | BRD4 (0.78) | BRD4 | |
| SCHEMBL12111070 | 0.82 | BRD4 (0.73) | BRD4EGFR | |
| SCHEMBL24625520 | 0.82 | EGFR (0.68) | BRD4EGFR | |
| SCHEMBL29793775 | 0.82 | EGFR (0.68) | BRD4EGFR | |
| SCHEMBL31163056 | 0.82 | BRD4 (0.76) | BRD4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858914-B2 | Pyrimidine small-molecule compound and application thereof | WENZHOU MEDICAL UNIVERSITY (CN) | 2024-01-02 | — | — | US | disclosed |
| US-20230312529-A1 | PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF | WENZHOU MEDICAL UNIVERSITY (CN) | 2023-10-05 | — | — | US | disclosed |
| CN-112778282-B | Pyrimidine micromolecule compound and application thereof | 温州医科大学 | 2022-07-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312529-A1 | PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF | PDGFRB, PDGFRA, RB1 | BRD4 1398/4885EGFR 966/4885 |
| US-11858914-B2 | Pyrimidine small-molecule compound and application thereof | PDGFRB, PDGFRA, RB1 | BRD4 1398/4885EGFR 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.