Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.52 |
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.48 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.47 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794496 | 0.93 | CRBN (0.64) | CRBNDDB1ARHPGDSIKZF1 | |
| SCHEMBL29794471 | 0.87 | CRBN (0.63) | CRBNDDB1ARHPGDS | |
| SCHEMBL29794454 | 0.86 | CRBN (0.64) | CRBNDDB1HPGDSALDH1A1CHRM2 | |
| SCHEMBL21907062 | 0.85 | CRBN (0.61) | CRBNDDB1ARHPGDSIRAK1 | |
| SCHEMBL31348171 | 0.85 | CRBN (0.66) | CRBNDDB1ARHPGDSIKZF1 | |
| SCHEMBL29794444 | 0.85 | CRBN (0.63) | CRBNDDB1ARHPGDSIRAK1 | |
| SCHEMBL30938328 | 0.84 | CRBN (0.72) | CRBNDDB1ARIKZF1IKZF2 | |
| SCHEMBL22566243 | 0.84 | CRBN (0.79) | CRBNDDB1ARIKZF1IKZF2 | |
| SCHEMBL25024933 | 0.83 | CRBN (0.69) | CRBNDDB1ARHPGDSIKZF1 | |
| SCHEMBL20305764 | 0.83 | CRBN (0.74) | CRBNDDB1ARIKZF1IKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188819-A1 | SOS1 PROTEOLYSIS MODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |
| CN-115043817-A | SOS1 proteolysis regulator and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-09-13 | — | — | CN | disclosed |