Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123530 | 1.00 | KDM4E (0.43) | KDM4EMAPK1DDB1CRBNIDO1 | |
| SCHEMBL29789752 | 0.77 | KDM1A (0.34) | — | |
| SCHEMBL23123288 | 0.77 | KDM1A (0.34) | — | |
| SCHEMBL25973432 | 0.72 | KDM4E (0.46) | KDM4EMAPK1DDB1CRBNIDO1 | |
| SCHEMBL17679904 | 0.72 | KDM4E (0.49) | KDM4EMAPK1IDO1NAMPTRORC | |
| SCHEMBL24290027 | 0.71 | KDM4E (0.45) | KDM4EMAPK1DDB1CRBNIDO1 | |
| SCHEMBL23123401 | 0.71 | PGR (0.36) | — | |
| SCHEMBL29789656 | 0.71 | PGR (0.36) | — | |
| SCHEMBL30844822 | 0.70 | KDM4E (0.46) | KDM4EMAPK1IDO1NAMPTRORC | |
| SCHEMBL31654230 | 0.70 | RORC (0.48) | KDM4EIDO1NAMPTRORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031540-A1 | SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | Bial-R&D Investments, S.A. (PT) | 2022-07-27 | — | — | EP | disclosed |