Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738388 | 0.89 | NPC1 (0.39) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL29447536 | 0.83 | NPC1 (0.39) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL1876428 | 0.83 | FGFR1 (0.45) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL3856673 | 0.83 | FGFR1 (0.45) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL3037362 | 0.83 | NPC1 (0.39) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL2794301 | 0.81 | HTT (0.48) | HTTCYP11B1CYP11B2FGFR1HPGD | |
| SCHEMBL3081829 | 0.79 | CYP11B1 (0.39) | HTTCYP11B1CYP11B2MAPK1TNF | |
| SCHEMBL6489900 | 0.79 | FGFR1 (0.45) | HTTFGFR1ALDH1A1NPC1MEN1 | |
| SCHEMBL2967845 | 0.79 | ACSS2 (0.38) | HTTCYP11B1CYP11B2FGFR1MAPK1 | |
| SCHEMBL3852750 | 0.77 | NPC1 (0.47) | HTTFGFR1HPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259213-A1 | PYRROLOPYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN MEDICINE | SHANGHAI MEDICILON INC. (CN) | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259213-A1 | PYRROLOPYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN MEDICINE | GIPR, REN, BDKRB1 | HTT 4296/4885CYP11B1 293/4885CYP11B2 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.