Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389927 | 1.00 | TGFBR1 (0.49) | TGFBR1MAPK14THRB | |
| SCHEMBL25822562 | 0.85 | TGFBR1 (0.38) | TGFBR1MAPK14THRB | |
| SCHEMBL23418760 | 0.84 | TGFBR1 (0.38) | TGFBR1MAPK14THRB | |
| SCHEMBL30156053 | 0.79 | TGFBR1 (0.37) | TGFBR1MAPK14THRB | |
| SCHEMBL25084820 | 0.79 | TGFBR1 (0.37) | TGFBR1MAPK14THRB | |
| SCHEMBL19683489 | 0.75 | TGFBR1 (0.59) | TGFBR1MAPK14 | |
| SCHEMBL11992061 | 0.74 | TGFBR1 (0.66) | TGFBR1MAPK14 | |
| SCHEMBL23389936 | 0.74 | CCR1 (0.40) | TGFBR1MAPK14THRB | |
| SCHEMBL29796504 | 0.74 | CCR1 (0.40) | TGFBR1MAPK14THRB | |
| SCHEMBL23389751 | 0.71 | TGFBR1 (0.37) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |